LATS activity, exophthalmos and digital clubbing associated with myxoedema.
نویسنده
چکیده
RIACH, I.C.F. (1966) The Stella Index-A relationship between the area of the sella turcica and the lateral area of the skull. Brit. J. Radiol. 39, 824. SMrrH, D.W., BLiZZARD, R.M. & WILKINS, L. (1957) The mental prognosis in hypothyroidism of infancy and childhood. Pediatrics, 19, 1011. VON HARNACK, G.A. (1953) Eineiige Zwillinge mit diskordanter Hypothyreose. Arch. Kinderheilk, 146, 60. VON HARNACK, G.A., HORST, W., LENZ, W. & ZUKSCHWERDT, L. (1958) Homotransplantation of thyroid tissue in uniovular twins. Germ. med. Mth. 3, 172. WARKANY, J. & SELKIRK, J. (1955) Discordant monozygotic twins. Amer. J. Dis. Child. 89, 144. WILKINS, L. (1965) The Diagnosis and Treatment ofEndocrine Disorders in Childhood and Adolescence, 3rd edn. Thomas, Springfield, Illinois.
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Kriss et al. (1964) postulated that the destruction of the thyroid gland by disease (hyperthyroidism or thyroiditis) or by therapeutic agents (especially 1311) results in the release of an antigen of thyroid cell origin which then stimulates the production of the antibody, LATS. The antibody is then fixed to the tissues of the legs, the phenomenon being facilitated by a number of factors such a...
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Case 1 showed recurrence of hyperthyroidism accompanied by pretibial myxedema and digital clubbing 14 years after thyroidectomy for Graves' disease. Case 2 had had pretibial myxedema for the past 20 years and myxedema tuberosum at the right shoulder for the past 10 years, and on admission showed exophthalmos and digital clubbing with thyroid gland demonstrating histological picture of chronic t...
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Studies of thyroid stimulating activity of serum from thyrotoxic patients has revealed an abnormal prolonged response in the mouse present in 40-60% of patients depending on the criteria used. This agent designated long acting thyroid stimulator (LATS) is a 7S globulin. Transplacental passage of LATS accounts for neonatal thyrotoxicosis-a self-limited disease. LATS is also more readily detected...
متن کاملThe aetiology and pathogenesis of hyperthyroidism.
Studies of thyroid stimulating activity of serum from thyrotoxic patients has revealed an abnormal prolonged response in the mouse present in 40-60% of patients depending on the criteria used. This agent designated long acting thyroid stimulator (LATS) is a 7S globulin. Transplacental passage of LATS accounts for neonatal thyrotoxicosis-a self-limited disease. LATS is also more readily detected...
متن کاملAcute endocrine ophthalmopathy in a 12-year-old boy with long-acting thyroid stimulator.
The aetiology of ophthalmopathy associated with thyroid disease is unknown. Excessive secretion of pituitary thyrotropin (TSH) had been suggested as a cause of exophthalmos (thyrotropic) (Falconer and Alexander, 195I). However, assays for thyrotropic hormone in patients with endocrine ophthalmopathy failed to reveal an elevation of TSH in the blood either before or during the development of acu...
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عنوان ژورنال:
- Postgraduate medical journal
دوره 44 511 شماره
صفحات -
تاریخ انتشار 1968